Basic Information
VIS ID
TVIS44024193
Fusion event
HTLV-1-BIK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
43525129/43129123 (Hg38)
End
43525129/43129123 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
BIK
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p ; hsa-mir-9-5p ; hsa-mir-125b-1-3p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-1281/Upstream/1205826; hsa-let-7a-3/Downstream/2071831;
Nearest TSS
ENST00000624155/Upstream/18375; ENST00000472378/Downstream/13841;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/17519, chr22-CpG: 82/Downstream/13784
Nearest cancer related gene
BIK(TSG, No orient, 0)
Upstream sequence
ACGCTGGCCTCTCTGGCCACGTCCTCAGGGCCACTTTCCCCCTCTCCTGAACTCCTTCCTTCTCTGGTCCCCTCGAGCTCCTTCCCAGTCCCCACCCTCC
Downstream sequence
TGGGCTTCCCCTTGGCACTCCGCTGTCACCCGTCTGGCCCCATTGCCGGGGCCTGCCCCGAGCCTGACTCCTCTGCTTTGCTCCCACAGGTGTCCTGCGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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