Basic Information
VIS ID
TVIS44024195
Fusion event
HTLV-1-EFCAB6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
44039208/43643328 (Hg38)
End
44039208/43643328 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
EFCAB6
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-488-3p ; hsa-mir-4635 ; hsa-mir-3662
Nearest miRNA
hsa-mir-1281/Upstream/1720031; hsa-let-7a-3/Downstream/1557626;
Nearest TSS
ENST00000624155/Upstream/73185; ENST00000564696/Downstream/28942;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/208086, chr22-CpG: 53/Downstream/168739
Upstream sequence
ctaaatgaggagatcaaagtttaaaaaggcaaaataagccaactgttttctaggaagacacaagtggtaagaagtagagcaaagatttgaacacgagttg
Downstream sequence
gtcggactccaCGGGACAACATTGTCtcatagactcagcactggaagaaataacagagtatcaggttcaactttgtcctttactgatgagaaacccaaag
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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