Basic Information
VIS ID
TVIS44024202
Fusion event
HTLV-1-DRP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
100495949/101240960 (Hg38)
End
100495949/101240960 (Hg38)
Orient
-
Location type
Intronic
Target gene
DRP2
miRNAs that regulate target gene
hsa-mir-7641 ; hsa-mir-4656 ; hsa-mir-4695-3p ; hsa-mir-4699-5p ; hsa-mir-4446-3p
Nearest miRNA
hsa-let-7f-2/Upstream/6177734; hsa-mir-105-1/Downstream/5398854;
Nearest TSS
ENST00000429181/Upstream/9415; ENST00000491851/Downstream/46845;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/49212, chrX-CpG: 54/Downstream/50115
Upstream sequence
TAGTTAGCCTGGGGCTATGGGGCTCTGGATCTTCTGAGGAGAGATCTGAGGGAGGAAGAAGAAATCTACAGATTAGGAGCCTAGGTGGAAAAGCCAGACA
Downstream sequence
CATTATACCAACTTCTCCTGGGCTGAGCCTTCATAAAATGCCTCCCTTTGGCTGGAAGTGGGCAACAGAAACTAATGCAAAATCACATTCCAGGGTCGTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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