Basic Information
VIS ID
TVIS44024209
Fusion event
HTLV-1-COL4A5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
107903212/108659982 (Hg38)
End
107903212/108659982 (Hg38)
Orient
-
Location type
Intronic
Target gene
COL4A5
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-29b-3p ; hsa-mir-222-5p ; hsa-mir-3171 ; hsa-mir-4264 ; hsa-mir-4797-3p ; hsa-mir-936 ; hsa-mir-802 ; hsa-mir-3129-5p ; hsa-mir-199b-3p ; hsa-mir-199a-3p
Nearest miRNA
hsa-let-7f-2/Upstream/2020086; hsa-mir-105-1/Downstream/1395347;
Nearest TSS
ENST00000429181/Upstream/37306; ENST00000489230/Downstream/10053;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/568073, chrX-CpG: 31/Downstream/72647
Upstream sequence
tgtatattgttatgtttggattttagtcttccacattgctatttgttttatgctcctcctttgtccctggtttcctgttctgtttgggttcatcagatat
Downstream sequence
gctgtggtattccattctatctcctctattggcttttaagctctccctctttctactatttttaaatgattgctccaaagatttcagtgtgcactcataa
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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