Basic Information
VIS ID
TVIS44024214
Fusion event
HTLV-1-ARHGAP6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
11413560/11395440 (Hg38)
End
11413560/11395440 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARHGAP6
miRNAs that regulate target gene
hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-655-3p ; hsa-mir-374c-5p ; hsa-mir-5088-3p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p
Nearest miRNA
hsa-mir-3690-1/Upstream/76754; hsa-let-7f-2/Downstream/2194852;
Nearest TSS
ENST00000429181/Upstream/102027; ENST00000478462/Downstream/32333;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/255996, chrX-CpG: 62/Downstream/31967
Upstream sequence
AGACAGCAACATCTAATACATTTTAGAAAATATTCATCAAAAAACAAAAAGGAAGGACTCAATGGGGcagcagtgtgctgataaaacatttaacaactgg
Downstream sequence
ttctctggaggaaagctctgatttgcgccatttgttaatttccataatataaatactcattgtggcggattccagggtaccaaggtgaggacacaggaca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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