Basic Information
VIS ID
TVIS44024225
Fusion event
HTLV-1-IGSF1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q26.1
Reference genome
GRCh37/hg19
Start
130419385/131285411 (Hg38)
End
130419385/131285411 (Hg38)
Orient
-
Location type
Exonic
Target gene
IGSF1
miRNAs that regulate target gene
hsa-mir-425-5p ; hsa-mir-577 ; hsa-mir-148b-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-92a-3p ; hsa-mir-16-5p
Nearest miRNA
hsa-let-7f-2/Upstream/9914358; hsa-mir-105-1/Downstream/2883967;
Nearest TSS
ENST00000429181/Upstream/4065; ENST00000338616/Downstream/3649;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/202483, chrX-CpG: 26/Downstream/510494
Upstream sequence
AGTTGGGACTTGGTAATCCACAGGCTCTGCATATCCCTCTTTAAACAGCATGAATACCAAATCCTGCAGCCAGCCATGGCAGAGGATGTTAACATTACAC
Downstream sequence
CCAGGAAGAGCGGGGGTCTCAGCCTGAATCCAGAAGATGGGCTTGGGCAGTTGGCCTGGAAGGATAGAATGAACTGGAATTAGGTAAAGCAAGGATAGTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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