Basic Information
VIS ID
TVIS44024245
Fusion event
HTLV-1-PPEF1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p22.13
Reference genome
GRCh37/hg19
Start
18718220/18700101 (Hg38)
End
18718220/18700101 (Hg38)
Orient
-
Location type
Intronic
Target gene
PPEF1
miRNAs that regulate target gene
hsa-mir-3140-3p ; hsa-mir-3191-5p ; hsa-mir-4686 ; hsa-mir-4768-5p ; hsa-mir-5089-3p ; hsa-mir-627-3p ; hsa-mir-6728-3p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-888-3p
Nearest miRNA
hsa-mir-3690-1/Upstream/1274147; hsa-let-7f-2/Downstream/1316987;
Nearest TSS
ENST00000429181/Upstream/50; ENST00000472826/Downstream/7553;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/24622, chrX-CpG: 130/Downstream/283784
Upstream sequence
GAAGCAGTCACGTGGCCGCTGACTTTGCAGCCCATTACTTGAGTGCATCTCCAGGCCAGGAACAGAGCAGGGCTGGGGCAGAGAGCTGTGCTCACGGCCA
Downstream sequence
GTGCATTGTCTCCCAGATTCGTGGCTCTGGGCTTGCCTTCCCGGCTGAAAGGCAAAGCAGCCTGGCCCTGTTCTAGTTATTTCTTTGTGTATATATGTTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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