Basic Information
VIS ID
TVIS44024252
Fusion event
HTLV-1-IL1RAPL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
29239740/29221623 (Hg38)
End
29239740/29221623 (Hg38)
Orient
-
Location type
Intronic
Target gene
IL1RAPL1
miRNAs that regulate target gene
hsa-mir-151a-5p ; hsa-mir-4307 ; hsa-mir-6768-5p ; hsa-mir-8485 ; hsa-mir-4446-5p ; hsa-mir-3679-3p ; hsa-mir-6840-5p ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-574-5p ; hsa-mir-147a ; hsa-mir-7108-5p ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-6867-5p ; hsa-mir-644a ; hsa-mir-3911 ; hsa-mir-663b ; hsa-mir-5197-5p ; hsa-mir-599 ; hsa-mir-3161 ; hsa-mir-4279 ; hsa-mir-100-3p ; hsa-mir-539-5p
Nearest miRNA
hsa-mir-23c/Upstream/725960; hsa-let-7f-2/Downstream/352655;
Nearest TSS
ENST00000429181/Upstream/634224; ENST00000302196/Downstream/695840;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/1357568, chrX-CpG: 30/Downstream/1025432
Upstream sequence
AACATTTATCTTGAAAATCCAAAATTCCTAAAGCAAGGGATCATATACTGCATATGTTACCGTCATTATGCCAAAGGAGCAATGTATacacacacataca
Downstream sequence
cacacacacacacacacacacacacacacacacacacacacacacacacaTATGACAGACTTCTCCAGCTCTCTGAACTACAAGATGCTTTATAAAACCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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