Basic Information
VIS ID
TVIS44024255
Fusion event
HTLV-1-DMD integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
32810957/32792840 (Hg38)
End
32810957/32792840 (Hg38)
Orient
-
Location type
Intronic
Target gene
DMD
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-31-5p ; hsa-mir-155-5p ; hsa-mir-21-5p ; hsa-mir-16-5p ; hsa-mir-4446-5p ; hsa-mir-186-3p ; hsa-mir-561-3p ; hsa-mir-6499-3p ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-297 ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-2052 ; hsa-mir-8068 ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-3973 ; hsa-mir-511-3p ; hsa-mir-9-3p
Nearest miRNA
hsa-mir-23c/Upstream/151281; hsa-let-7f-2/Downstream/5231055;
Nearest TSS
ENST00000429181/Upstream/37900; ENST00000445233/Downstream/23713;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/1525938, chrX-CpG: 36/Downstream/933473
Nearest cancer related gene
DMD(TSG, No orient, 0)
Upstream sequence
ggataagtttagcaagagtatataaaaattctaaacatacatacacccaacacgagagctcccagatatataaagcaagtattagatctaaagggagagc
Downstream sequence
tagatgcaaatacagtaatatctgaggacttcaacaccccactctcagcattagatcacttagacaaaaaattaacaaagaaacattggcttgaaactgc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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