Basic Information
VIS ID
TVIS44024268
Fusion event
HTLV-1-UBA1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p11.3
Reference genome
GRCh37/hg19
Start
47056834/47197435 (Hg38)
End
47056834/47197435 (Hg38)
Orient
-
Location type
Intronic
Target gene
UBA1
miRNAs that regulate target gene
hsa-mir-1254 ; hsa-mir-1301-3p ; hsa-mir-744-5p ; hsa-mir-615-3p ; hsa-mir-324-5p ; hsa-mir-331-3p ; hsa-mir-27b-3p ; hsa-mir-222-3p ; hsa-mir-210-3p ; hsa-mir-182-5p ; hsa-mir-17-3p ; hsa-let-7b-5p ; hsa-mir-6834-5p ; hsa-mir-4278 ; hsa-mir-5010-5p ; hsa-mir-5187-5p ; hsa-mir-4525 ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-6875-5p ; hsa-mir-3126-5p ; hsa-mir-1272 ; hsa-mir-6732-5p ; hsa-mir-6805-5p ; hsa-mir-6794-5p ; hsa-mir-4716-3p ; hsa-mir-6822-5p ; hsa-mir-6750-5p ; hsa-mir-3591-3p ; hsa-mir-21-3p
Nearest miRNA
hsa-mir-1587/Upstream/1450311; hsa-let-7f-2/Downstream/389994;
Nearest TSS
ENST00000429181/Upstream/236; ENST00000490869/Downstream/5258;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/3229, chrX-CpG: 92/Downstream/20329
Upstream sequence
taagattagacaaagccctttcctctttgattgacacacagtatgctcttggtagatagtagGGAGCTCTTGTCATTGTGGTTGGTGCTAGTGACAAGTG
Downstream sequence
CCAAGATGGAATCTTAGGTACATTGGGATACTTAGTGTCATAAAAGTCTCAGTGTGGGAGGACTTGTGTGAACAGAAGACTCAGTGCCTAGAGGAGCACT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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