Basic Information
VIS ID
TVIS44024269
Fusion event
HTLV-1-CCDC120 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
48913559/49056030 (Hg38)
End
48913559/49056030 (Hg38)
Orient
-
Location type
Intronic
Target gene
CCDC120
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-6771-5p ; hsa-mir-4316 ; hsa-mir-4710 ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-4722-5p ; hsa-mir-6804-5p ; hsa-mir-1827 ; hsa-mir-589-5p ; hsa-mir-6746-5p ; hsa-mir-6840-3p ; hsa-mir-665 ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p
Nearest miRNA
hsa-mir-1587/Upstream/1468525; hsa-let-7f-2/Downstream/947118;
Nearest TSS
ENST00000429181/Upstream/2458; ENST00000482476/Downstream/2936;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/2066, chrX-CpG: 60/Downstream/15947
Upstream sequence
AGGGAAAATTGAGATAATGAAGAATAATGACTAACTAAAAAATGTATCCAAATCTATGAACTTTCCTGAGCTCCAGGGACAAGAGTTGGGATAGTGAGGG
Downstream sequence
TACCCTGTTATGTAAATGGTTCCTGCATTTTGTTTGGAGGGTAAGGAAAGTTCAAGAATGAGGGATACCAGTCGTATCTCAAAAATGTTTCTGAATCCAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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