Basic Information
VIS ID
TVIS44024289
Fusion event
HTLV-1-OPHN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q12
Reference genome
GRCh37/hg19
Start
67473938/68254096 (Hg38)
End
67473938/68254096 (Hg38)
Orient
-
Location type
Intronic
Target gene
OPHN1
miRNAs that regulate target gene
hsa-mir-548m ; hsa-mir-3187-3p ; hsa-mir-653-3p ; hsa-mir-4529-5p ; hsa-mir-6847-3p ; hsa-mir-539-5p ; hsa-mir-3185 ; hsa-mir-3190-5p ; hsa-mir-4756-3p ; hsa-mir-3919 ; hsa-mir-548o-3p ; hsa-mir-1323 ; hsa-mir-5680 ; hsa-mir-193b-3p ; hsa-mir-193a-3p ; hsa-mir-551b-5p ; hsa-mir-497-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-7156-3p ; hsa-mir-5007-3p ; hsa-mir-1272 ; hsa-mir-8084 ; hsa-mir-3662 ; hsa-mir-8058 ; hsa-mir-4529-3p ; hsa-mir-5009-5p ; hsa-mir-1269b ; hsa-mir-1269a ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p ; hsa-mir-92a-1-5p ; hsa-mir-4515 ; hsa-mir-1288-3p ; hsa-mir-4740-5p ; hsa-mir-3607-3p ; hsa-mir-1208 ; hsa-mir-7844-5p ; hsa-mir-6505-5p ; hsa-mir-4789-5p ; hsa-mir-7153-3p
Nearest miRNA
hsa-let-7f-2/Upstream/2235117; hsa-mir-105-1/Downstream/1768761;
Nearest TSS
ENST00000429181/Upstream/43828; ENST00000462972/Downstream/82356;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/121015, chrX-CpG: 71/Downstream/179008
Upstream sequence
ttgtctcactgctgcccaagactatggcttctatttgtaaacatctattacatgtttctctctcagaaactggatatgtcagcttctttcttaagcctct
Downstream sequence
cagctttcttagacttcaggggtaggtgtgcatagacctgctcactgtggaacaGTGCTTAAGACCTGCTGGAGGAACAAAAGTGGTACAAGCagcatga
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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