Basic Information
VIS ID
TVIS44024310
Fusion event
HTLV-1-DIAPH2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
96179229/96924230 (Hg38)
End
96179229/96924230 (Hg38)
Orient
+
Location type
Intronic
Target gene
DIAPH2
miRNAs that regulate target gene
hsa-mir-10b-5p ; hsa-mir-17-3p ; hsa-mir-4520-3p ; hsa-mir-4520-2-3p ; hsa-mir-20a-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-4473 ; hsa-mir-4671-3p ; hsa-mir-4778-3p ; hsa-mir-520f-3p ; hsa-mir-302c-3p ; hsa-mir-512-3p ; hsa-mir-641 ; hsa-mir-3617-5p
Nearest miRNA
hsa-let-7f-2/Upstream/1861004; hsa-mir-105-1/Downstream/9715584;
Nearest TSS
ENST00000429181/Upstream/40322; ENST00000627700/Downstream/640275;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/238863, chrX-CpG: 23/Downstream/3015106
Upstream sequence
GTCAGTGAAAGTGCATTTATAAGAAAACAAGGCATCGAGGCTTATGAATATGGAGAAAATTTGTGGAAATTAGCATTTATAAAGTGTTGAATGACTGCTT
Downstream sequence
GATATTACTTAGGAAACTTGTTCTATTTATTGACAGTTTTATATTATTGTCATTTAGAAAATAGATTACTATAATGGGAGGTTGTTTAGAGATATTTGTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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