Basic Information
VIS ID
TVIS44024382
Fusion event
HTLV-1-CTSS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
150723675/150751199 (Hg38)
End
150723675/150751199 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1F
Target gene
CTSS
miRNAs that regulate target gene
hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-769-5p ; hsa-mir-4786-5p ; hsa-mir-664a-5p ; hsa-mir-4794 ; hsa-mir-7162-3p ; hsa-mir-544b ; hsa-mir-6849-3p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-6765-3p ; hsa-mir-3622b-3p ; hsa-mir-3622a-3p ; hsa-mir-8066 ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-101-1/Upstream/199185; hsa-mir-1182/Downstream/794597;
Nearest TSS
ENST00000473358/Upstream/1108; ENST00000636087/Downstream/635;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/121474, chr1-CpG: 21/Downstream/174944
Upstream sequence
AATGAATTTCTGAGGAAGAGGAGAGTGTTATTTAGCTTCTCAGTGGGTGGAAGAATGATGTGGTTAATGATCTGAGAATAAGGTTGAGCATGGGAGGCTG
Downstream sequence
CAGAAGAAAAAGTTTAAATACAGAGAAATAATTTTAAGGATAGTTTGCTTAAAATCTGTTTAAttttgggatggagtcttgctccgttgccgaggctgga
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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