Basic Information
VIS ID
TVIS44024412
Fusion event
HTLV-1-LMX1A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
165175985/165206748 (Hg38)
End
165175985/165206748 (Hg38)
Orient
-
Location type
Intronic
Target gene
LMX1A
miRNAs that regulate target gene
hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-342-3p ; hsa-mir-377-3p ; hsa-mir-4743-3p ; hsa-mir-6888-3p ; hsa-mir-6868-3p ; hsa-mir-3182 ; hsa-mir-3120-5p ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-466 ; hsa-mir-4672 ; hsa-mir-3941 ; hsa-mir-362-3p ; hsa-mir-329-3p
Nearest miRNA
hsa-mir-101-1/Upstream/2864108; hsa-mir-1182/Downstream/701173;
Nearest TSS
ENST00000473358/Upstream/394020; ENST00000457106/Downstream/3879;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/88959, chr1-CpG: 79/Downstream/28516
Upstream sequence
GAATTGCACAGGGGTCCTGTGAGGTAGGACTAGCAGGCATTAGGGCCCTACCCTAGGGATGCACACAGCCTGAGGAACAAGGAAAAGTTGGTCCCACATA
Downstream sequence
AAGAGCCTTAGGGGTGGAGCTGAGGGCAGAATTCAGATCTAACCAGCTTCCTGCTCCACCCTTCCCCACACCTATGCCCTGTTTTATTTCTTCTCTCCCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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