Basic Information
VIS ID
TVIS44024420
Fusion event
HTLV-1-MFAP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.13
Reference genome
GRCh37/hg19
Start
17303547/16977052 (Hg38)
End
17303547/16977052 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
MFAP2
miRNAs that regulate target gene
hsa-mir-18a-3p ; hsa-mir-1287-5p ; hsa-mir-3135b ; hsa-mir-6128 ; hsa-mir-512-3p ; hsa-mir-2114-5p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-6778-3p ; hsa-mir-4707-3p ; hsa-mir-4454
Nearest miRNA
hsa-mir-12136/Upstream/118031; hsa-mir-101-1/Downstream/300837;
Nearest TSS
ENST00000473358/Upstream/7267; ENST00000446261/Downstream/1224;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/10432, chr1-CpG: 75/Downstream/3004
Upstream sequence
GGGAGTAAGGCTAATCCCCCAGCCCCTGGGGCAAACAAGTTCCCTCCTGAGCCAGGGACCAACCCCCAGAGTTCCCATCAGCGTGTCCAGTGCGGTCCCT
Downstream sequence
GGCTGAGCCAGGCACATCTGAGCAGCCAGGCCTCGGTGACCCGGCAAGGCCCTTACCGATCTGGTCGCTATAGTGGGTGTACTGGACGTGGTCAGGGAAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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