Basic Information
VIS ID
TVIS44024437
Fusion event
HTLV-1-RNASEL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
182549970/182580835 (Hg38)
End
182549970/182580835 (Hg38)
Orient
-
Location type
Intronic
Target gene
RNASEL
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-29a-3p ; hsa-mir-4776-3p ; hsa-mir-8070 ; hsa-mir-192-3p ; hsa-mir-4480 ; hsa-mir-409-3p ; hsa-mir-1250-3p ; hsa-mir-153-5p ; hsa-mir-3919 ; hsa-mir-3925-5p ; hsa-mir-4756-3p ; hsa-mir-520d-5p ; hsa-mir-524-5p ; hsa-mir-5696 ; hsa-mir-579-3p ; hsa-mir-589-5p ; hsa-mir-664b-3p
Nearest miRNA
hsa-mir-101-1/Upstream/2142445; hsa-mir-1182/Downstream/10135493;
Nearest TSS
ENST00000473358/Upstream/24699; ENST00000566297/Downstream/8421;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/188407, chr1-CpG: 34/Downstream/23405
Nearest cancer related gene
RNASEL(TSG, No orient, 0)
Upstream sequence
ATCATCTTTCCTTCATAGTCTATTTCCTCAGGCAGAATGTAGGTCTGTGTGTGGATCCTGAGAGCTGGGCTGTTTACAGGCAGTGGAGGCAGCCAGGCTG
Downstream sequence
TACCTGGACTGAAACACCTCATGGTGAAGCACTTCCCTTGGATTAAGCTCTATTTAGTCAGCTGCTCGTGCCATAATGGCAATAGGATTATCAGCTAAGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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