Basic Information
VIS ID
TVIS44024439
Fusion event
HTLV-1-GNB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.33
Reference genome
GRCh37/hg19
Start
1784279/1852840 (Hg38)
End
1784279/1852840 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
GNB1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-103a-3p ; hsa-mir-101-3p ; hsa-mir-16-5p ; hsa-mir-589-3p ; hsa-mir-106a-5p ; hsa-mir-17-5p ; hsa-let-7b-5p ; hsa-mir-218-5p ; hsa-mir-493-3p ; hsa-mir-3064-3p ; hsa-mir-3138 ; hsa-mir-1227-3p ; hsa-mir-891a-5p ; hsa-mir-4795-5p ; hsa-mir-6838-5p ; hsa-mir-6501-3p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-2278 ; hsa-mir-582-5p ; hsa-mir-889-3p ; hsa-mir-324-5p ; hsa-mir-302a-5p ; hsa-mir-1277-5p ; hsa-mir-212-3p ; hsa-mir-132-3p ; hsa-mir-5692a ; hsa-mir-4520-3p ; hsa-mir-874-5p ; hsa-mir-4533 ; hsa-mir-1252-5p ; hsa-mir-6125 ; hsa-mir-3120-3p ; hsa-mir-1287-5p ; hsa-mir-2392 ; hsa-mir-3135b ; hsa-mir-3907 ; hsa-mir-3928-3p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4524b-3p ; hsa-mir-4768-3p ; hsa-mir-766-5p
Nearest miRNA
hsa-mir-12136/Upstream/513132; hsa-mir-101-1/Downstream/1275135;
Nearest TSS
ENST00000473358/Upstream/20555; ENST00000412228/Downstream/37561;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/70138, chr1-CpG: 199/Downstream/37126
Upstream sequence
GCCCCTGAGTGGAGTGCAACTTACGGGCCTACCCTACACTCAGGAGCCAGCAACAGCCCCTCATCCTGCTCTCACCAACCCAGCTCCACATCTGCCACAC
Downstream sequence
CCAGTCACGCCCCCTTCTGAACCCTCAACTGGTTCTTTTGTGGTTCTTCTCTCAAGTCGAGGATCCACTCCTTATTCCCTTTCCCTGAATGTACCCCAGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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