Basic Information
VIS ID
TVIS44024475
Fusion event
HTLV-1-KCNH1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
210860921/210687579 (Hg38)
End
210860921/210687579 (Hg38)
Orient
+
Location type
Intronic
Target gene
KCNH1
miRNAs that regulate target gene
hsa-mir-296-3p ; hsa-mir-335-5p ; hsa-mir-34a-5p ; hsa-mir-7704 ; hsa-mir-615-5p ; hsa-mir-2467-3p ; hsa-mir-4257 ; hsa-mir-6890-5p ; hsa-mir-7843-5p ; hsa-mir-6879-5p ; hsa-mir-6735-5p ; hsa-mir-4632-5p ; hsa-mir-4436b-3p ; hsa-mir-6753-5p ; hsa-mir-1911-3p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-505-3p ; hsa-mir-4290 ; hsa-mir-1233-3p ; hsa-mir-7113-3p ; hsa-mir-4673 ; hsa-mir-339-5p ; hsa-mir-4645-5p ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-4687-5p ; hsa-mir-508-5p
Nearest miRNA
hsa-mir-101-1/Upstream/1064069; hsa-mir-1182/Downstream/1390034;
Nearest TSS
ENST00000473358/Upstream/3650; ENST00000472734/Downstream/331611;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/3659, chr1-CpG: 92/Downstream/445746
Upstream sequence
TAGGCAGCCCCCTGAACATCACTGTCTCAACCAATGGACAGGTGAGCCAGGGACGAGCTTCCTACCCTGCAGAAATGCCTGGTTCTTCCTTTGAGAATCA
Downstream sequence
GAGGGGTAAAACCAGCAACCCCCAGGGGACAAGGCAAAAGGAGTTTTTACAGAGCTGATGTGGTCTGACAGCTTTGCTGACCTGGAGTCAAGGGCTCTGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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