Basic Information
VIS ID
TVIS44024477
Fusion event
HTLV-1-TRAF5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
211548177/211374835 (Hg38)
End
211548177/211374835 (Hg38)
Orient
+
Location type
UTR3
Target gene
TRAF5
miRNAs that regulate target gene
hsa-mir-4459 ; hsa-mir-4433a-3p ; hsa-mir-4768-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-383-5p ; hsa-mir-574-5p ; hsa-mir-1277-5p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-3941 ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-26b-5p
Nearest miRNA
hsa-mir-101-1/Upstream/1751325; hsa-mir-1182/Downstream/702778;
Nearest TSS
ENST00000473358/Upstream/5906; ENST00000448567/Downstream/7968;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/47541, chr1-CpG: 42/Downstream/7762
Upstream sequence
TAACTTCTTTTAAGTAGTTGATGTGGAAAACATTTTAAAGTGAATTTGTCAAAATGCTGGTTTTGTGTTTTATCCAACTTTTGTGCATATATATAAAGTA
Downstream sequence
TGTCATGGCATGGTTTGCTTAGGAGTTCAGAGTTCCTTCATCATCGAAATAGTGATTAAGTGATCCCAGAACAAGGAATACTAGAGTAAAAAGCACCTCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate