Basic Information
VIS ID
TVIS44024508
Fusion event
HTLV-1-PGBD5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q42.13
Reference genome
GRCh37/hg19
Start
230473551/230337805 (Hg38)
End
230473551/230337805 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
PGBD5
miRNAs that regulate target gene
hsa-mir-5698 ; hsa-mir-143-5p ; hsa-mir-6879-3p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-215-3p ; hsa-mir-6773-3p ; hsa-mir-5693 ; hsa-mir-500b-3p ; hsa-mir-335-5p
Nearest miRNA
hsa-mir-101-1/Upstream/1875653; hsa-mir-1182/Downstream/682023;
Nearest TSS
ENST00000473358/Upstream/1510; ENST00000633012/Downstream/39840;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/4701, chr1-CpG: 19/Downstream/19165
Upstream sequence
atgactgtttaatttgttctttatagtaacccccatcaggcaggcagaagaggtatgattcccctcacggtgcagaggagacaggactgagggctaaaca
Downstream sequence
tttgcccaagagtccagggccaacaaAGAGGATGTGTGGGGACTCAGTCAGCAATTTTTAAACGTCGTTTCATGCTGCTTCCATGAACATCACCAAAGGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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