Basic Information
VIS ID
TVIS44024516
Fusion event
HTLV-1-SIPA1L2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q42.2
Reference genome
GRCh37/hg19
Start
232758815/232623069 (Hg38)
End
232758815/232623069 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
SIPA1L2
miRNAs that regulate target gene
hsa-mir-103a-3p ; hsa-mir-16-5p ; hsa-mir-484 ; hsa-mir-543 ; hsa-mir-573 ; hsa-mir-3616-5p ; hsa-mir-7158-3p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-219a-1-3p ; hsa-mir-4795-5p ; hsa-mir-1284 ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-3140-3p ; hsa-mir-520f-3p ; hsa-mir-302c-3p
Nearest miRNA
hsa-mir-101-1/Upstream/1603145; hsa-mir-1537/Downstream/1001083;
Nearest TSS
ENST00000473358/Upstream/61511; ENST00000430921/Downstream/95002;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/995700, chr1-CpG: 173/Downstream/6273
Upstream sequence
acctaagtgcagggaatacagcagtaaaccagaaatgtccctgcctgtttgctgcttatgttccaTTATTAAAATCGAACAGGAGGATGGGTGGGGGTGG
Downstream sequence
ATGGTGCTCGTTTAGCTGGAAGTTACTGGAGATACAAGAGCAGGGCTCCCTGCTGTCTCTCCTCACTCATTCCCAACCCACTAACGGCTGGGAAGCCAGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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