Basic Information
VIS ID
TVIS44024517
Fusion event
HTLV-1-KCNK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q42.2
Reference genome
GRCh37/hg19
Start
233768257/233632511 (Hg38)
End
233768257/233632511 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
KCNK1
miRNAs that regulate target gene
hsa-mir-340-5p ; hsa-mir-124-3p ; hsa-mir-33a-5p ; hsa-mir-1277-5p ; hsa-mir-5011-5p ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-4759 ; hsa-mir-3924 ; hsa-mir-3941 ; hsa-mir-5580-3p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-6074 ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-4666a-5p ; hsa-mir-6716-5p ; hsa-mir-4646-5p ; hsa-mir-204-3p ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-3152-5p ; hsa-mir-6836-3p ; hsa-mir-342-3p ; hsa-mir-377-3p
Nearest miRNA
hsa-mir-101-1/Upstream/8292; hsa-mir-1537/Downstream/673956;
Nearest TSS
ENST00000473358/Upstream/2904; ENST00000472869/Downstream/4013;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/17707, chr1-CpG: 118/Downstream/272196
Upstream sequence
AAGGTCAGTTAATGAACTAATGAACCTCAGGGTTCATTTTTTTATAACCTTACCGGGACTGGATTTCTTTCTTTCTTTTTTTCTTAAGCTGCCAACAGTT
Downstream sequence
CTTGTCAGGATTCAATGTAGATGCTGCTGCTGGCTGTCCTGGTGGTGGTTTGATCTCTGTTGTGTGGGCTTCACAAGGGGCTCTGGTTCAGTGATTCCAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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