Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene3894627539081316394871773918266839198335392121093921786539176150391816683917198839175796392037773920694139198833392015313916760139169761391700223917162139210149392108193920316039203675392074013920760039216726
Basic Information
VIS ID
TVIS44024563
Fusion event
HTLV-1-MACF1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p34.3
Reference genome
GRCh37/hg19
Start
39682398/39216726 (Hg38)
End
39682398/39216726 (Hg38)
Orient
-
Location type
Intronic
Target gene
MACF1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-16-5p ; hsa-mir-296-3p ; hsa-mir-615-3p ; hsa-mir-125a-5p ; hsa-mir-222-3p ; hsa-mir-30d-5p ; hsa-mir-92a-3p ; hsa-let-7e-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p
Nearest miRNA
hsa-mir-12136/Upstream/1127397; hsa-mir-101-1/Downstream/1537629;
Nearest TSS
ENST00000473358/Upstream/1461; ENST00000485063/Downstream/40923;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/110539, chr1-CpG: 115/Downstream/191620
Upstream sequence
CTGCCATAGCAATAATGCTTGGGGCACAGAGGGGGCAATTTTAGTGGTCTACTTTTTTTTTTTATCTTTCCTGTATCATTGAGATTTCTTCCCTGGAACC
Downstream sequence
TAGAAGAAAGAATTGCCTATATCTAAAAGTGCTTGGAGATAAACGTATAGCAAAAGGGCCTTTCCTGTAACCAACAAAGAAGTATAGGAAAGTCTAAAAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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