Basic Information
VIS ID
TVIS44024584
Fusion event
HTLV-1-OSBPL9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p32.3
Reference genome
GRCh37/hg19
Start
52206889/51741217 (Hg38)
End
52206889/51741217 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1B
Target gene
OSBPL9
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-296-3p ; hsa-mir-125a-5p ; hsa-mir-190a-3p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-5011-5p ; hsa-mir-6867-5p ; hsa-mir-6083 ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-574-5p ; hsa-mir-4642 ; hsa-mir-3713 ; hsa-mir-4711-5p ; hsa-mir-4740-3p
Nearest miRNA
hsa-mir-12136/Upstream/681114; hsa-mir-101-1/Downstream/95127;
Nearest TSS
ENST00000473358/Upstream/11183; ENST00000467064/Downstream/3873;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/11068, chr1-CpG: 56/Downstream/137289
Upstream sequence
TCCTTCTGAAAAAAGTAGTGTTATTTAACTTAAGTATTAGAAAGGTAGTAGGAAGTACCGACATACAGTTTTGAGGCAGTTTGATATTCTTCTACAAGTC
Downstream sequence
TAGTTATATTATTTTAGAAATTCCCCTTAAATTGGCCCAGATGTGTATGTTTCTCTTTCTCTCTCTATTAAACTGGATACATAGATTCTGGATGATATAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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