Basic Information
VIS ID
TVIS44024606
Fusion event
HTLV-1-MIER1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
GRCh37/hg19
Start
67396198/66930515 (Hg38)
End
67396198/66930515 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
MIER1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-30e-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-580-3p ; hsa-mir-4324 ; hsa-mir-4251 ; hsa-mir-20b-3p ; hsa-mir-3137 ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-3686 ; hsa-mir-190a-3p ; hsa-mir-298 ; hsa-mir-338-3p ; hsa-mir-4530 ; hsa-mir-922 ; hsa-mir-5586-5p ; hsa-mir-410-3p ; hsa-mir-5197-3p ; hsa-mir-450b-5p ; hsa-mir-4511 ; hsa-mir-4696
Nearest miRNA
hsa-mir-101-1/Upstream/301998; hsa-mir-11399/Downstream/1253003;
Nearest TSS
ENST00000473358/Upstream/272; ENST00000479067/Downstream/2137;
Nearest CpG islands
chr1-CpG: 77/Target, None/Upstream, None/Downstream
Upstream sequence
CCCCCTCCCTGTCCCGGAgccgggcgcccccggccctgggccggggAGGAGTGGAGTGGGCCTGGCCAGGAGAGGCCCGGCCCTGCTGGCGCCGCTGCCC
Downstream sequence
ACCTGTTGTCCGGAACAGGCCATTCTCTGGGCGGGAGCTTCGCCTGGAACTTAGTTGGGATGGGTCCGGGGGTAGGAGGAAGCGGAGGCGTACTTGGACT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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