Basic Information
VIS ID
TVIS44024609
Fusion event
HTLV-1-WLS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
GRCh37/hg19
Start
68687303/68221620 (Hg38)
End
68687303/68221620 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
WLS
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-let-7b-5p ; hsa-mir-186-5p ; hsa-mir-3682-3p ; hsa-mir-331-5p ; hsa-mir-6793-3p ; hsa-mir-4678
Nearest miRNA
hsa-mir-101-1/Upstream/38010; hsa-mir-11399/Downstream/2846011;
Nearest TSS
ENST00000473358/Upstream/45243; ENST00000425820/Downstream/10067;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/58101, chr1-CpG: 83/Downstream/9305
Upstream sequence
TTTTCTATATCTTTTCCATGTCTGAGGCATTCTGCTCTGGGGCAAATTACAACCTAAATAAGAACAGATAAAATATATGGGAACTGAGTAAAAGAAATAG
Downstream sequence
AACCTCAAAAAGGGCTGCTCTGCCTGGAAAGAAGGCTGGAATTCATAAAACATGGAACGTAACTTTTTTAGTGATCACCTGAAGGCAAGCTTGTTAAACA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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