Basic Information
VIS ID
TVIS44024629
Fusion event
HTLV-1-TTLL7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
84464377/83998694 (Hg38)
End
84464377/83998694 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
TTLL7
miRNAs that regulate target gene
hsa-mir-92a-3p ; hsa-mir-24-3p ; hsa-mir-135b-5p ; hsa-mir-135a-5p ; hsa-mir-4662b ; hsa-mir-4647 ; hsa-mir-4426 ; hsa-mir-548e-5p ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-1294 ; hsa-mir-4316 ; hsa-mir-4679 ; hsa-mir-4677-3p ; hsa-mir-136-3p
Nearest miRNA
hsa-mir-101-1/Upstream/6938492; hsa-mir-11399/Downstream/1135100;
Nearest TSS
ENST00000473358/Upstream/46313; ENST00000646678/Downstream/331;
Nearest CpG islands
chr1-CpG: 93/Target, None/Upstream, None/Downstream
Upstream sequence
TAAACCAGCAGGGAGCCTCCTCGTTCACCCAACCCGACCCCGCCCGCCCGAGTCTCCCATCTGGAGCCTAAAAACTGAGCTGAGATCACAGCAACTGACC
Downstream sequence
CCGTCCCCTCCGCCCTCTCCCTCCCCCATTCTGCCCAAACCTCTCAGGGCACGAATGGTGCTGAATCATTTGCACGAACGCAGCAGCTCCCCGTTCCGCG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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