Basic Information
VIS ID
TVIS44024634
Fusion event
HTLV-1-CTNNBIP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.22
Reference genome
GRCh37/hg19
Start
9946541/9886483 (Hg38)
End
9946541/9886483 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
CTNNBIP1
miRNAs that regulate target gene
hsa-mir-29b-3p ; hsa-mir-215-5p ; hsa-mir-335-5p ; hsa-mir-192-5p ; hsa-mir-744-5p ; hsa-mir-3180-5p ; hsa-mir-501-5p ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-671-5p ; hsa-mir-2115-5p ; hsa-mir-4786-3p ; hsa-mir-5739 ; hsa-mir-5091 ; hsa-mir-6837-5p ; hsa-mir-4685-5p ; hsa-mir-7113-5p ; hsa-mir-488-5p ; hsa-mir-4422 ; hsa-mir-6835-3p ; hsa-mir-29c-3p ; hsa-mir-29a-3p
Nearest miRNA
hsa-mir-12136/Upstream/734706; hsa-mir-101-1/Downstream/80898;
Nearest TSS
ENST00000473358/Upstream/8307; ENST00000492735/Downstream/6754;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/61874, chr1-CpG: 113/Downstream/23304
Nearest cancer related gene
CTNNBIP1(TSG, No orient, 0)
Upstream sequence
gacaatcgaatcgaatatatcttctgacgttgccatgtgtcccgtaggggacaaaattgccaggtcgagagcactgCTTTAAAGAAGCAGCTGACACGTA
Downstream sequence
CTCTGgcttactctgtgccttgcaccattggcaactctcaggtaagtgaatcattcagtcttcgccacacacgtccctacagggctttacaaatgggcat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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