Basic Information
VIS ID
TVIS44024636
Fusion event
HTLV-1-CNOT11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
101870980/101254518 (Hg38)
End
101870980/101254518 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2A
Target gene
CNOT11
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-149-5p ; hsa-mir-196a-5p ; hsa-mir-25-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/4456165; hsa-mir-10b/Downstream/54932;
Nearest TSS
ENST00000437798/Upstream/1652; ENST00000462489/Downstream/7913;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/978, chr2-CpG: 119/Downstream/53384
Upstream sequence
GCCGGGCATCCCATCAGGATCTTCTGATAGGTGTCCTGTAGTGCCCTTATCTAAGAAGGGCAACCCTTTGTATTGGCCTGAGATGCCTTTAGGGTACAGG
Downstream sequence
TACTTAACCTGCTTCTAAGAAGCTTGTGACTGCCCAGAAAGTGAATGTAACACAGGTTTGTGGTCAAAACTCACCACCTAggcctggctaggtggctcac
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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