Basic Information
VIS ID
TVIS44024646
Fusion event
HTLV-1-RANBP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q13
Reference genome
GRCh37/hg19
Start
109672850/109056394 (Hg38)
End
109672850/109056394 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
RANBP2
miRNAs that regulate target gene
hsa-mir-708-5p ; hsa-mir-106b-3p ; hsa-mir-421 ; hsa-mir-423-3p ; hsa-mir-186-5p ; hsa-mir-125b-5p ; hsa-let-7g-5p ; hsa-mir-92a-3p ; hsa-let-7e-5p ; hsa-let-7a-5p ; hsa-mir-7152-5p ; hsa-mir-3074-5p ; hsa-mir-1200 ; hsa-mir-378a-5p ; hsa-mir-539-5p ; hsa-mir-3124-3p ; hsa-mir-3140-5p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-3973 ; hsa-mir-551b-5p ; hsa-mir-6507-3p ; hsa-mir-4311 ; hsa-mir-4439 ; hsa-mir-943 ; hsa-mir-6826-3p ; hsa-mir-3136-5p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-6795-3p ; hsa-mir-6887-3p ; hsa-mir-5003-5p ; hsa-mir-542-3p ; hsa-mir-4504 ; hsa-mir-642b-3p ; hsa-mir-642a-3p ; hsa-mir-4501 ; hsa-mir-8087 ; hsa-mir-7161-5p ; hsa-mir-548u
Nearest miRNA
hsa-mir-1285-2/Upstream/6624028; hsa-mir-10b/Downstream/85096;
Nearest TSS
ENST00000437798/Upstream/67022; ENST00000309415/Downstream/72536;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/24620, chr2-CpG: 227/Downstream/71735
Nearby gene
EDAR(-67022) ;
Upstream sequence
taactaggtctagagatgcaggccaccatgcctcactaacttttgaatttttttgtagagacgggagtctcattatgctgcttaggctagattcgaagtt
Downstream sequence
ctggcattaagtgttcctcccgtctcggcctcccaaagtgctgggattacaggcatgaaccaccacacctggccAGCTTATAGTCTTTAGATCTCTTCTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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