Basic Information
VIS ID
TVIS44024678
Fusion event
HTLV-1-ZRANB3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
135979547/135221977 (Hg38)
End
135979547/135221977 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2F
Target gene
ZRANB3
miRNAs that regulate target gene
hsa-mir-6855-5p ; hsa-mir-5096 ; hsa-mir-3170 ; hsa-mir-4662a-5p ; hsa-mir-193b-5p ; hsa-mir-6890-5p ; hsa-mir-575 ; hsa-mir-4676-5p ; hsa-mir-6858-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/364104; hsa-mir-10b/Downstream/443420;
Nearest TSS
ENST00000437798/Upstream/14459; ENST00000483021/Downstream/6335;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/169289, chr2-CpG: 36/Downstream/309423
Upstream sequence
TGTCCATGCTAGAGGCTGCTTGGGGATTCTGGTATTCAAAATCCTAGCCATCTCCTCCTAAAAGAATATTATTACATGGTACACTATCTATCTATATCTA
Downstream sequence
TATTCGGTTTAGTAGAAAACCTGTAACTGAAAGTTTGGTCATCTCCAACATATTATCTTTTAAACATCGATATAATGGACCATGAGTTTTAAAAGTTTCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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