Basic Information
VIS ID
TVIS44024702
Fusion event
HTLV-1-TBR1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
162281214/161424703 (Hg38)
End
162281214/161424703 (Hg38)
Orient
+
Location type
UTR3
Target gene
TBR1
miRNAs that regulate target gene
hsa-mir-542-5p ; hsa-mir-6889-5p ; hsa-mir-6777-5p ; hsa-mir-3162-3p ; hsa-mir-6777-3p ; hsa-mir-7151-5p ; hsa-mir-181c-3p ; hsa-mir-15b-5p
Nearest miRNA
hsa-mir-128-1/Upstream/1016821; hsa-mir-10b/Downstream/7158240;
Nearest TSS
ENST00000437798/Upstream/330; ENST00000606386/Downstream/2750;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/505, chr2-CpG: 82/Downstream/2367
Upstream sequence
TCCGACCCGCCAAGTCTCGGCCTCCACATTAACCATAGGATGTTGACTCTAGAACCTGGACCCACCCAGCGCGTCCTTTCTTATCCCCGAGtggatggat
Downstream sequence
ggatggatggatggTAGGGATGTTAATAATTTTAGTGGAACAAAGCCTGTGAAATGATTGTACATAGTGTTAATTTATTGTAACGAATGGCTAGTTTTTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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