Basic Information
VIS ID
TVIS44024707
Fusion event
HTLV-1-FAM49A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p24.2
Reference genome
GRCh37/hg19
Start
16811309/16630041 (Hg38)
End
16811309/16630041 (Hg38)
Orient
+
Location type
Intronic
Target gene
FAM49A
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-8485 ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-107 ; hsa-mir-103a-3p ; hsa-mir-2110 ; hsa-mir-25-3p ; hsa-mir-3150a-3p ; hsa-mir-32-5p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-4271 ; hsa-mir-450a-2-3p ; hsa-mir-4725-3p ; hsa-mir-621 ; hsa-mir-6763-5p ; hsa-mir-6780b-5p ; hsa-mir-6810-5p ; hsa-mir-6857-5p ; hsa-mir-92a-1-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p
Nearest miRNA
hsa-mir-3125/Upstream/3892597; hsa-mir-10b/Downstream/2718388;
Nearest TSS
ENST00000437798/Upstream/68559; ENST00000423925/Downstream/35787;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/121487, chr2-CpG: 29/Downstream/908847
Upstream sequence
GGAAGCCGAGCATGGAAGAAGCCCAGAGACCAGATAGTGACTAACTGGGAGTGGCCGTGGCTCAGGCAGTCCTAGACAGTCAGAGGCCAACACGCCGGTG
Downstream sequence
ATGATGGTGATGGGGCAGAAGATACCAACCCTTattcactgagcattgactgtgtgccaggcatggtctagacatcacctggatgttctaccagccctcg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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