Basic Information
VIS ID
TVIS44024724
Fusion event
HTLV-1-ZNF385B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
180326891/179462164 (Hg38)
End
180326891/179462164 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2G
Target gene
ZNF385B
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p
Nearest miRNA
hsa-mir-10b/Upstream/2148282; hsa-mir-1244-1/Downstream/398672;
Nearest TSS
ENST00000437798/Upstream/188333; ENST00000629145/Downstream/74339;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/197228, chr2-CpG: 55/Downstream/398981
Upstream sequence
GAATTTTTCCTTTTTATACTTAATATTGCACTAAACAGAGGCATGCAGTGAAAGGACTGATGGTCACATTCTTTCCTGTATTCACAAGCACCTTGTACAA
Downstream sequence
CATCTCATTATTATTCCAAAAAACAAAGCAATGCCCATATTACTGTTTAACACTCATTAAACCAAGTTAGCTCACTTTGATAAGGAATTCTGAAATCATT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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