Basic Information
VIS ID
TVIS44024727
Fusion event
HTLV-1-PPP1R1C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
182947224/182082497 (Hg38)
End
182947224/182082497 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2G
Target gene
PPP1R1C
miRNAs that regulate target gene
hsa-mir-146a-5p ; hsa-mir-3119 ; hsa-mir-5191 ; hsa-mir-6894-5p ; hsa-mir-3679-5p ; hsa-mir-1185-5p ; hsa-mir-4521 ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-4428 ; hsa-mir-7158-5p ; hsa-mir-767-3p ; hsa-mir-6826-5p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-3977 ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4712-5p ; hsa-mir-4768-3p ; hsa-mir-770-5p ; hsa-mir-936
Nearest miRNA
hsa-mir-10b/Upstream/776845; hsa-mir-1244-1/Downstream/2296478;
Nearest TSS
ENST00000437798/Upstream/21034; ENST00000494189/Downstream/21104;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/189705, chr2-CpG: 53/Downstream/633469
Upstream sequence
CATCGTCTCTAAAGCATGTGTGCACGTGTCTGGCATAAAATCAAGGGTGGAAAGTTACCCTGAAGGTCAAACGGACAAGGTTTTCTGAGTTTCTgcttgg
Downstream sequence
cctggtaagacagccttggtcatggaggaggcctgattctgaagactgggtcaattctgtcacttgcatttgtttactgccctgccttcgctggctctgc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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