Basic Information
VIS ID
TVIS44024728
Fusion event
HTLV-1-PDE1A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
183364130/182499403 (Hg38)
End
183364130/182499403 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2G
Target gene
PDE1A
miRNAs that regulate target gene
hsa-mir-133b ; hsa-mir-133a-3p ; hsa-mir-5587-5p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-3691-3p ; hsa-mir-4698 ; hsa-mir-8063 ; hsa-mir-1264
Nearest miRNA
hsa-mir-10b/Upstream/1193751; hsa-mir-1244-1/Downstream/1879572;
Nearest TSS
ENST00000437798/Upstream/72355; ENST00000469118/Downstream/22909;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/606611, chr2-CpG: 53/Downstream/216563
Upstream sequence
gtagctgggactacaggcgcccgcaactgtactccgctaattttttgtattttcagtagagacagggtttcaccatgttagccataatttttgtattttt
Downstream sequence
agtagggacaggattttaccatgttgaccaggctagtctcaaactcctgacctcaaatgagccaccagccttggcctcccaaagggctgggattacaggc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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