Basic Information
VIS ID
TVIS44024731
Fusion event
HTLV-1-STAT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
191858344/190993618 (Hg38)
End
191858344/190993618 (Hg38)
Orient
+
Location type
Intronic
Target gene
STAT1
miRNAs that regulate target gene
hsa-mir-145-5p ; hsa-mir-146a-5p ; hsa-mir-34a-5p ; hsa-mir-615-3p ; hsa-mir-653-5p ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-4693-5p ; hsa-mir-5009-3p ; hsa-mir-501-5p ; hsa-mir-1183 ; hsa-mir-500a-5p ; hsa-mir-605-5p ; hsa-mir-140-5p ; hsa-mir-150-5p ; hsa-mir-223-3p ; hsa-mir-203a-3p ; hsa-mir-450a-5p ; hsa-mir-155-5p
Nearest miRNA
hsa-mir-10b/Upstream/1860507; hsa-mir-1244-1/Downstream/15789616;
Nearest TSS
ENST00000437798/Upstream/9904; ENST00000431351/Downstream/20337;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/111745, chr2-CpG: 70/Downstream/20264
Nearest cancer related gene
STAT1(TSG, No orient, 0)
Upstream sequence
ATCAGAAGTAATTTGAATAAATAATCAATTTGGGATTCATGCTGGACATGTCACTGTAGCTGCCACCGCTGCCACGGCCACCCTTGCTGCTACAGCTGCT
Downstream sequence
GCCCTGACTCTCTGCACCACGGGTAACTGAAGGAAAGGAATGAGATAGGCTGTTCTGGGAGAGTAAATGTCTTCCCCGACTCTGCCCCCTGGAACGCAAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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