Basic Information
VIS ID
TVIS44024746
Fusion event
HTLV-1-ERBB4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q34
Reference genome
GRCh37/hg19
Start
213106200/212241475 (Hg38)
End
213106200/212241475 (Hg38)
Orient
+
Location type
Intronic
Target gene
ERBB4
miRNAs that regulate target gene
hsa-mir-372-3p ; hsa-mir-19a-3p ; hsa-mir-302d-3p ; hsa-mir-146a-5p ; hsa-mir-145-5p ; hsa-mir-221-3p ; hsa-mir-302b-3p ; hsa-mir-193a-3p ; hsa-mir-146b-5p
Nearest miRNA
hsa-mir-10b/Upstream/4486594; hsa-mir-1244-1/Downstream/184788;
Nearest TSS
ENST00000437798/Upstream/116294; ENST00000434559/Downstream/187772;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1764663, chr2-CpG: 86/Downstream/295981
Nearest cancer related gene
ERBB4(TSG, No orient, 0)
Upstream sequence
ACATCATCAAAATGATCTTAAATTGTATAAAGCATGTATATGAAACAGGTCCAAGATTTTATTAACTTACCCACACTATATTAAGAAACATTTAACACAG
Downstream sequence
GTAATAACCACATTGTATAATTTCATCTGATTGTTAATATTAGCTATTATCTTAGAAACTAATAATAACAATGTTTCTATCCACAGAAAGATGTAACAAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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