Basic Information
VIS ID
TVIS44024843
Fusion event
HTLV-1-PLEK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p14
Reference genome
GRCh37/hg19
Start
68598997/68371865 (Hg38)
End
68598997/68371865 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
PLEK
miRNAs that regulate target gene
hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-3180-5p ; hsa-mir-4452 ; hsa-mir-183-3p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-mir-3923
Nearest miRNA
hsa-mir-1301/Upstream/2013537; hsa-mir-10b/Downstream/731817;
Nearest TSS
ENST00000437798/Upstream/6281; ENST00000474788/Downstream/16077;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/51886, chr2-CpG: 98/Downstream/95050
Upstream sequence
cacttctctgtatacaaccacaacgagtttagtttttttttgacagcccacatcaaattgctgactcatagagctccttttttcccacatgctcatttcc
Downstream sequence
cacaccttataagtctttacaaaatattattaaagagaaaggctgtatcttatttaatttcaatttgcatttctttgattgcagttgaagcaatcaatta
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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