Basic Information
VIS ID
TVIS44024853
Fusion event
HTLV-1-DCTN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
74595103/74367976 (Hg38)
End
74595103/74367976 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA2S ; FRA2E
Target gene
DCTN1
miRNAs that regulate target gene
hsa-mir-1296-5p ; hsa-mir-361-5p ; hsa-mir-93-5p ; hsa-mir-25-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/4114971; hsa-mir-10b/Downstream/722836;
Nearest TSS
ENST00000437798/Upstream/1782; ENST00000416630/Downstream/37;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/168680, chr2-CpG: 57/Downstream/23650
Upstream sequence
GAAGGGCACTGTGAGGCTAGAGTCTGCCAGGCAATCTCAGTTCTGGCCAATCCTGGACCCCCACCCTGGGGTGAGGGAGTCAGGAGTCACTTACTGCTCA
Downstream sequence
TAGCGGTGTAGCGTGGCCTGCAGCAGGCTCAGCGAGTACACCAGTCCAGCAGCAAAGCTGAGTTGCTCCCCAGCAGCTCCTCGCAGCCCAGGCCGCTCTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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