Basic Information
VIS ID
TVIS44024882
Fusion event
HTLV-1-CHMP3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
86749638/86522515 (Hg38)
End
86749638/86522515 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2L
Target gene
CHMP3
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-let-7b-5p ; hsa-mir-125b-5p ; hsa-mir-432-5p ; hsa-mir-8064 ; hsa-mir-500b-3p ; hsa-mir-133b ; hsa-mir-133a-3p ; hsa-mir-3912-5p ; hsa-mir-5587-5p ; hsa-mir-9-5p ; hsa-mir-383-3p ; hsa-mir-3065-3p ; hsa-mir-6760-3p ; hsa-mir-3617-3p ; hsa-mir-34c-3p ; hsa-mir-129-5p ; hsa-mir-7850-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-3613-3p ; hsa-mir-888-5p ; hsa-mir-3646 ; hsa-mir-3662 ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-7152-5p ; hsa-mir-4303 ; hsa-mir-6740-3p ; hsa-mir-1233-3p ; hsa-mir-1225-3p ; hsa-mir-4778-3p ; hsa-mir-3182 ; hsa-mir-6751-3p ; hsa-mir-1199-5p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-6748-3p ; hsa-mir-141-5p ; hsa-mir-16-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/329407; hsa-mir-10b/Downstream/672271;
Nearest TSS
ENST00000437798/Upstream/9980; ENST00000597638/Downstream/19798;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/80191, chr2-CpG: 60/Downstream/40336
Upstream sequence
CCAACACAACAACCCTGTCTAGGAATCCTTCCTGTCAGCAAAAGCTTAGGTGCTGCAGAAGCCAGGTGAACCAAATAGCCACTGATTTCCTGGGGCTAGT
Downstream sequence
CTGGTCAGCCCAAGTGAAGATTCCTCTCTTAGACCTGTTCCTCTCCCTGTGTTTCCAGTGTCTGTTAATGGCCCTGCAGTCTCTTTCCAGGCTCAAAGGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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