Basic Information
VIS ID
TVIS44024900
Fusion event
HTLV-1-INPP4A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
99063219/98446756 (Hg38)
End
99063219/98446756 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2A
Target gene
INPP4A
miRNAs that regulate target gene
hsa-mir-1301-3p ; hsa-mir-877-5p ; hsa-mir-421 ; hsa-mir-23b-3p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-3613-3p ; hsa-mir-3127-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/1648403; hsa-mir-10b/Downstream/2862694;
Nearest TSS
ENST00000437798/Upstream/1806; ENST00000463367/Downstream/72391;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1371, chr2-CpG: 84/Downstream/161425
Upstream sequence
GTCTGCTTACCTGGCCACCTTACTCATCATGTAGCTACTTTTTTCATTTAGATTATTCTGTCTCAGGGTGTTTAATCTGCTTGGGTAAGTCTTGTTTCCC
Downstream sequence
AACTAGATTCAGAACCAAGGGCAGATATTATAGTGCCTCCCTGTTTTCAAAACTGGATATTTTGTAGTATTGCTGTTAAACTGAATATTAGCGTTTTTTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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