Basic Information
VIS ID
TVIS44024949
Fusion event
HTLV-1-RAF1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p25.2
Reference genome
GRCh37/hg19
Start
12635059/12593560 (Hg38)
End
12635059/12593560 (Hg38)
Orient
-
Location type
Intronic
Target gene
RAF1
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-125b-5p ; hsa-mir-195-5p ; hsa-mir-497-5p ; hsa-mir-186-5p ; hsa-mir-23b-3p ; hsa-mir-16-5p ; hsa-mir-4799-5p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-6516-3p ; hsa-mir-7111-3p ; hsa-mir-3682-5p ; hsa-mir-520f-5p ; hsa-mir-4291 ; hsa-mir-6789-5p ; hsa-mir-6077 ; hsa-mir-486-3p ; hsa-mir-4254 ; hsa-mir-4660 ; hsa-mir-3690 ; hsa-mir-6736-3p ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-6813-5p ; hsa-mir-6085 ; hsa-mir-6743-5p ; hsa-mir-4688 ; hsa-mir-3134 ; hsa-mir-8082 ; hsa-mir-4534 ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-132-3p ; hsa-mir-7-1-3p ; hsa-mir-125a-5p
Nearest miRNA
hsa-mir-12127/Upstream/2198998; hsa-let-7g/Downstream/2902679;
Nearest TSS
ENST00000440867/Upstream/1492; ENST00000626378/Downstream/6195;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/36008, chr3-CpG: 89/Downstream/70000
Nearest cancer related gene
RAF1(OG, No orient, 0)
Upstream sequence
GGTTTTATCATCTAAAGTTTCAACGAGTCCCCATGTTTTAACAGCAGCCTCCAAAGTGGCTCTCATCCAGTTAACCTGCACATGTGTTTGCCATGGGCTG
Downstream sequence
CCGGTGAAGGTGCTGTTGACTGGATGGGAGAGATCCACACTATGTTTGGAGCTACCTTCTATCTAGAAAAATGGATCCATATGGGACACCATATGGGAAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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