Basic Information
VIS ID
TVIS44024962
Fusion event
HTLV-1-IQSEC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p25.2
Reference genome
GRCh37/hg19
Start
13082306/13040806 (Hg38)
End
13082306/13040806 (Hg38)
Orient
-
Location type
Intronic
Target gene
IQSEC1
miRNAs that regulate target gene
hsa-mir-92a-1-5p ; hsa-mir-589-3p ; hsa-mir-378a-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-2355-3p ; hsa-mir-676-3p ; hsa-mir-6749-3p ; hsa-mir-642a-5p ; hsa-mir-6721-5p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-3616-3p ; hsa-mir-3655 ; hsa-mir-4469 ; hsa-mir-1914-5p ; hsa-mir-5193 ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-4650-5p ; hsa-mir-7843-5p ; hsa-mir-6735-5p ; hsa-mir-6879-5p ; hsa-mir-4632-5p ; hsa-mir-4436b-3p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-12127/Upstream/2646244; hsa-let-7g/Downstream/2455433;
Nearest TSS
ENST00000440867/Upstream/18210; ENST00000418189/Downstream/1634;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/45619, chr3-CpG: 76/Downstream/32321
Upstream sequence
tcccttttaaagcctctgggtttttcccatgtggtttcccctctgtctggaacacctgtgctccccatctcaacccagcaaactcctccagacactttac
Downstream sequence
cacctggctcagctgtcacctcctccatgaagcccccgcacccAGCCCTGCTCCTCTTTCAAGACTCTGACCGCGACTCATGCCTGGCTAGCTGAGCCCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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