Basic Information
VIS ID
TVIS44025054
Fusion event
HTLV-1-KAT2B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
20145949/20104457 (Hg38)
End
20145949/20104457 (Hg38)
Orient
+
Location type
Intronic
Target gene
KAT2B
miRNAs that regulate target gene
hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-25-3p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-mir-17-5p ; hsa-mir-92b-3p ; hsa-mir-142-3p ; hsa-mir-127-5p ; hsa-mir-539-5p
Nearest miRNA
hsa-mir-12127/Upstream/789526; hsa-let-7g/Downstream/33108;
Nearest TSS
ENST00000440867/Upstream/63759; ENST00000469085/Downstream/7137;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/63523, chr3-CpG: 62/Downstream/81340
Upstream sequence
ACCTCCCCCACGTCCCCACCATCACGTCATGTTGATGAGGAAAGGGAAGTAGAGAGGAACAACCTGTGAAAATTAGGAGAATCAATATTCGGAGTAAAAC
Downstream sequence
CTCACTGCCATGACCACATGGGGAATTAAAAAAACCACATACCACCACAGCATGATGTCTCACTGATACTGATCTTCTCAAAAATGGGTAATATTACTGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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