Basic Information
VIS ID
TVIS44025060
Fusion event
HTLV-1-RARB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p24.2
Reference genome
GRCh37/hg19
Start
25598403/25556912 (Hg38)
End
25598403/25556912 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA3A
Target gene
RARB
miRNAs that regulate target gene
hsa-mir-16-2-3p ; hsa-mir-30c-5p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-33a-3p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-545-5p ; hsa-mir-4307 ; hsa-mir-6792-5p ; hsa-mir-6838-5p ; hsa-let-7c-5p ; hsa-mir-548c-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-578 ; hsa-mir-1-3p ; hsa-mir-106a-5p ; hsa-mir-146a-5p ; hsa-mir-146b-5p
Nearest miRNA
hsa-mir-12127/Upstream/5419271; hsa-let-7g/Downstream/107961;
Nearest TSS
ENST00000440867/Upstream/98602; ENST00000460195/Downstream/59029;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/726312, chr3-CpG: 125/Downstream/107153
Nearest cancer related gene
RARB(TSG, No orient, 0)
Upstream sequence
AGATGCAAGAGAAGTCTGGGTCACACACCACAGCCCTAATTTGAGAAACTGGTCTGTGACAGTTGGCAATTATGAGTTTGAATTTCCATAATGGATTGGA
Downstream sequence
ATTTCTCTCATCTTTGCATTTCAAAGCCAAGGGCAAGGAATAGTTATTATTTTCTCATAGTAATTCTTGTAAACAATTCCTGATGTGCAAGGTAGGTCAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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