Basic Information
VIS ID
TVIS44025095
Fusion event
HTLV-1-CACNA2D3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
54273608/54239581 (Hg38)
End
54273608/54239581 (Hg38)
Orient
+
Location type
Intronic
Target gene
CACNA2D3
miRNAs that regulate target gene
hsa-mir-18a-3p ; hsa-mir-8058 ; hsa-mir-4529-3p ; hsa-mir-5009-5p ; hsa-mir-1269b ; hsa-mir-1269a ; hsa-mir-6516-3p ; hsa-mir-92a-1-5p ; hsa-mir-6503-3p ; hsa-mir-8075 ; hsa-mir-8069 ; hsa-mir-664a-3p ; hsa-mir-758-5p ; hsa-mir-4728-3p ; hsa-mir-6074
Nearest miRNA
hsa-let-7g/Upstream/1393029; hsa-mir-12124/Downstream/1612911;
Nearest TSS
ENST00000440867/Upstream/42210; ENST00000478466/Downstream/33193;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/116583, chr3-CpG: 33/Downstream/386581
Nearest cancer related gene
CACNA2D3(TSG, No orient, 0)
Upstream sequence
AGATTTTCAGTAGCTGCATTTGAAAAGCTCTGTTAATATCTGTTGTGACCCCTGTTGCCACATGAGGTGTCCAAGCCAAAAGTGTTGGATCAGAAGAAGG
Downstream sequence
GAGATCATTGTGTGCTAAGGGGGTTCAGGAAGAACAAATGTAGTTCTACTGGGTGCCATGGTTCAGAATCATCACTTCACTTCCTAAAAAGCAGACAATC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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