Basic Information
VIS ID
TVIS44025105
Fusion event
HTLV-1-FHIT integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.2
Reference genome
GRCh37/hg19
Start
60357869/60372136 (Hg38)
End
60357869/60372136 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA3B
Target gene
FHIT
miRNAs that regulate target gene
hsa-mir-143-3p ; hsa-mir-217 ; hsa-mir-331-3p ; hsa-mir-625-5p
Nearest miRNA
hsa-let-7g/Upstream/4519542; hsa-mir-12124/Downstream/245669;
Nearest TSS
ENST00000440867/Upstream/291296; ENST00000475527/Downstream/879248;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1321918, chr3-CpG: 48/Downstream/878796
Nearest cancer related gene
FHIT(TSG, No orient, 0)
Upstream sequence
AGAGAGGCATTTTCATTACATACATCACTGCATTGTGGCGGTATCTCCAGAATGGCTTAAATGCATCATGTACTTTTACCCAAATGGTCTCTGAACAAGA
Downstream sequence
GTGTTGGAAGAGATGTCAGTTCTTGGGCCCTGACAATGTTGTTTCCTAGCCTAAAAAGTCTGAGAAATGTGGAATATTCCTACCTCCTTCTGTGAGAAGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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