Basic Information
VIS ID
TVIS44025124
Fusion event
HTLV-1-ROBO1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
79127702/79078552 (Hg38)
End
79127702/79078552 (Hg38)
Orient
+
Location type
Intronic
Target gene
ROBO1
miRNAs that regulate target gene
hsa-mir-217 ; hsa-mir-218-5p ; hsa-mir-423-3p ; hsa-mir-25-3p ; hsa-mir-6835-3p ; hsa-mir-146a-5p ; hsa-mir-377-3p ; hsa-mir-1185-2-3p ; hsa-mir-876-3p ; hsa-mir-3591-5p ; hsa-mir-921 ; hsa-mir-3606-5p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-636 ; hsa-mir-3140-3p ; hsa-mir-4445-5p ; hsa-mir-508-3p ; hsa-mir-8062 ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-561-3p ; hsa-mir-548at-5p ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548as-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-299-5p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-4782-3p ; hsa-mir-6766-3p ; hsa-mir-219a-5p ; hsa-mir-6885-3p ; hsa-mir-1273e ; hsa-mir-4327 ; hsa-mir-1287-5p ; hsa-mir-3135b ; hsa-mir-330-3p ; hsa-mir-29a-3p ; hsa-mir-218-2-3p
Nearest miRNA
hsa-let-7g/Upstream/3340189; hsa-mir-12124/Downstream/429335;
Nearest TSS
ENST00000440867/Upstream/59093; ENST00000473938/Downstream/511390;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/59136, chr3-CpG: 29/Downstream/687936
Nearest cancer related gene
ROBO1(TSG, No orient, 0)
Upstream sequence
GAGTATCAAAATATTCTTATTTCAGATGATTAAGAACAAAAGCTCCAGAATTGCATACTATTTTTACACTTTCCAACCAACAGAGGGTGATGGGATGTCC
Downstream sequence
CATATATGCTAGATTTCCAAGCCATAATAGTTCTTGTAGTCAACAATTAAACAATCATTAGAAAACATGGATCACTCGAAAAGTAGGAGTGAAAATACTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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